Log In
Username:
Password:
Forgot Password?

View Sample Newsletter
Search Related Resources
PubMed
OMIM
GeneReviews
OMMBID > Part 4: > Chapter 22: > Abstract
Back to TOC



Chapter 22: Tumor Genome Instability

Contributors: Daniel P. Cahill, Christoph Lengauer

Abstract

Genetic instability has long been recognized as a cardinal feature of neoplasia.1, 2 However, the causal role of genetic instability in the formation of cancer has only more recently been studied. Accumulating evidence has strengthened the proposal that genetic instability is required early during tumor progression. Instability drives mutations in oncogenes and tumor suppressor genes, providing the tumor cell with a selective growth advantage.3 While numerous oncogenes and tumor suppressor genes have been identified in the last 20 years, the molecular details underlying genetic instability are just now being revealed.



DOI Reference Number : http://dx.doi.org/10.1036/ommbid.32

The content above is only an excerpt.
For full access subscribe today or log into an existing user account below.

Purchase Chapter PDF
Access All of OMMBID
Already a user? Sign in here
Username:
Password:
Forgot your Username/Password?